Codon optimization of the adenoviral fiber negatively impacts structural protein expression and viral fitness
نویسندگان
چکیده
منابع مشابه
Codon optimization of the adenoviral fiber negatively impacts structural protein expression and viral fitness
Codon usage adaptation of lytic viruses to their hosts is determinant for viral fitness. In this work, we analyzed the codon usage of adenoviral proteins by principal component analysis and assessed their codon adaptation to the host. We observed a general clustering of adenoviral proteins according to their function. However, there was a significant variation in the codon preference between th...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep27546